The 2021 Nippon Professional Baseball (NPB) Draft was held on October 11, , for the 57th time at the Grand Prince Hotel Takanawa to assign amateur baseball players to the NPB. It was arranged with the special cooperation of Taisho Pharmaceutical with official naming rights. The draft was officially called "The Professional Baseball Draft Meeting supported by Lipovitan D ". It has been sponsored by Taisho Pharmaceutical for the 9th consecutive year since 2013.
Only the first round picks will be done by bid lottery. from 2019, the Professional Baseball Executive Committee has decided that the Central League and the Pacific League will be given the second round of waiver priority alternately every other year, and in 2021 Central League received the waiver priority. And since it was held in the middle of the regular season, the second round of Waiver priority was decided according to the ranking as of October 10, the day before. From the third round the order was reversed continuing in the same fashion until all picks were exhausted. It ends when all teams are "selected" or when the total number of selected players reaches 120. Also, if the number of players has not reached 120, we will continue to hold a "developmental squad player selection meeting" with the participation of the desired team.