The 2021 Kilkenny Senior Hurling Championship was the 127th staging of the Kilkenny Senior Hurling Championship since its establishment by the Kilkenny County Board in 1887. The championship began on 2 October 2021 and ended on 7 November 2021.
Ballyhale Shamrocks entered the championship as the defending champions. Rower-Inistioge were relegated from the championship after being beaten in a playoff by Erin's Own.
The final was played on 7 November 2021 at UPMC Nowlan Park in Kilkenny, between Ballyhale Shamrocks and O'Loughlin Gaels, in what was their first meeting in a final in five years. Ballyhale Shamrocks won the match by 3âÂÂ19 to 3âÂÂ15 to claim their 19th championship title overall and a fourth title in succession.
T. J. Reid was the championship's top scorer with 1-31.
Promoted from the Kilkenny Intermediate Hurling Championship
Relegated to the Kilkenny Intermediate Hurling Championship