The 2016 Copa Libertadores final stages were played from 26 April to 27 July 2016. A total of 16 teams competed in the final stages to decide the champions of the 2016 Copa Libertadores. Atlético Nacional won the title by defeating Independiente del Valle in the finals.
<section begin=Qualified teams /> The winners and runners-up of each of the eight groups in the second stage qualified for the final stages.
<section end=Qualified teams />
<section begin=Seeding /> The qualified teams were seeded in the final stages according to their results in the second stage, with the group winners seeded 1âÂÂ8, and the group runners-up seeded 9âÂÂ16.
<section end=Seeding />
<section begin=Format /> In the final stages, the 16 teams played a single-elimination tournament, with the following rules:
<section begin=Bracket /><noinclude> The bracket of the final stages was determined by the seeding as follows:
</noinclude> <section end=Bracket />
The first legs were played on 26âÂÂ28 April, and the second legs were played on 3âÂÂ5 May 2016. <section begin=Round of 16 />
<section end=Round of 16 />
Atlético Nacional won 4âÂÂ2 on aggregate and advanced to the quarterfinals (Match S1).
UNAM won 2âÂÂ1 on aggregate and advanced to the quarterfinals (Match S2).
Tied 2âÂÂ2 on aggregate, Nacional won on away goals and advanced to the quarterfinals (Match S3).
Atlético Mineiro won 2âÂÂ1 on aggregate and advanced to the quarterfinals (Match S4).
São Paulo won 5âÂÂ3 on aggregate and advanced to the quarterfinals (Match S4).
Boca Juniors won 5âÂÂ2 on aggregate and advanced to the quarterfinals (Match S3).
Independiente del Valle won 2âÂÂ1 on aggregate and advanced to the quarterfinals (Match S2).
Rosario Central won 4âÂÂ0 on aggregate and advanced to the quarterfinals (Match S1).
The first legs were played on 11âÂÂ12 and 17 May, and the second legs were played on 18âÂÂ19 and 24 May 2016. <section begin=Quarterfinals />
<section end=Quarterfinals />
Atlético Nacional won 3âÂÂ2 on aggregate and advanced to the semifinals (Match F1).
Tied 3âÂÂ3 on aggregate, Independiente del Valle won on penalties and advanced to the semifinals (Match F2).
Tied 2âÂÂ2 on aggregate, Boca Juniors won on penalties and advanced to the semifinals (Match F2).
Tied 2âÂÂ2 on aggregate, São Paulo won on away goals and advanced to the semifinals (Match F1).
The first legs were played on 6âÂÂ7 July, and the second legs were played on 13âÂÂ14 July 2016. <section begin=Semifinals />
<section end=Semifinals />
Atlético Nacional won 4âÂÂ1 on aggregate and advanced to the finals.
Independiente del Valle won 5âÂÂ3 on aggregate and advanced to the finals.
The first leg was played on 20 July, and the second leg was played on 27 July 2016. <section begin=Finals /><noinclude>
</noinclude>
Atlético Nacional won 2âÂÂ1 on aggregate.<section end=Finals />