The 2006 NCAA Division I softball tournament was the twenty-fifth annual tournament to determine the national champion of NCAA women's collegiate softball. Held during May and June 2006, sixty-four Division I college softball teams contested the championship. The tournament featured eight regionals of eight teams, each in a double elimination format. The 2006 Women's College World Series was held in Oklahoma City, Oklahoma from June 1 through June 6 and marked the conclusion of the 2006 NCAA Division I softball season. Arizona won their seventh championship by defeating Northwestern two games to none in the championship series. Arizona pitcher Alicia Hollowell was named Women's College World Series Most Outstanding Player.
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The following players were members of the All-Tournament Team.