The 2006 Northwestern Wildcats softball team represented Northwestern University in the 2006 NCAA Division I softball season. The Wildcats were coached by Kate Drohan, who led his fifth season. The Wildcats finished with a record of 50âÂÂ15. They competed in the Big Ten Conference, where they finished first with an 16âÂÂ3 record.
The Wildcats were invited to the 2006 NCAA Division I softball tournament, where they swept the NCAA Evanston Regional, claimed the Super Regional in three games, and then completed a run to the title game of the Women's College World Series where they fell to champion Arizona.