The 1853 yellow fever epidemic of the Gulf of Mexico and Caribbean islands resulted in thousands of fatalities. Over 9,000 people died of yellow fever in New Orleans alone, around 8% of the total population. Many of the dead in New Orleans were recent Irish immigrants living in difficult conditions and without any acquired immunity. There was a stark racial disparity in mortality rates: "7.4% of whites who contracted yellow fever died, while only 0.2% of blacks perished from the disease." As historian Kathryn Olivarius observed in ', "For enslaved blacks, the story was different. Immunity protected them from yellow fever, but as embodied capital, they saw the social and monetary value of their acclimation accrued to their white owners."
The epidemic was an international news story. A newspaper in Cambridge, England, published this evocative description of the scene in the Crescent City:
One of the most popular treatments in New Orleans was by Marie Laveau, whose practice of voodoo and/or the healing arts with yellow fever was so esteemed that "a committee of citizens was appointed to wait upon her, and beg her to lend her aid to the feversmitten, numbers of whom she saved." In addition to death toll in New Orleans:
Multiple books were written by contemporary doctors and public health officials about the epidemic; the New Orleans city directory of 1854 included a long essay on the series of major epidemics suffered by the city since before the Louisiana Purchase. The fall preceding the 1853 outbreak there were a small number of cases in the Caribbean; the Jamaican cases were documented, in part, in The Lancet by a surgeon of the Royal Navy.