The enzyme xylonate dehydratase () catalyzes the chemical reaction:
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is <small>D</small>-xylonate hydro-lyase (2-dehydro-3-deoxy-<small>D</small>-xylonate-forming). Other names in common use include <small>D</small>-xylo-aldonate dehydratase, <small>D</small>-xylonate dehydratase, and <small>D</small>-xylonate hydro-lyase. This enzyme participates in pentose and glucuronate interconversions.