In enzymology, a vomifoliol dehydrogenase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are (6S,9R)-6-hydroxy-3-oxo-alpha-ionol and NAD<sup>+</sup>, whereas its 3 products are (6R)-6-hydroxy-3-oxo-alpha-ionone, NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is vomifoliol:NAD<sup>+</sup> oxidoreductase. Other names in common use include vomifoliol 4'-dehydrogenase, and vomifoliol:NAD<sup>+</sup> 4'-oxidoreductase.