Vanadium(V) oxytrifluoride is a chemical compound with the formula VOF<sub>3</sub>. It is one of several vanadium(V) oxyhalides. VOF<sub>3</sub> is a yellowish orange powder that is sensitive to moisture. Characteristic of early metal fluorides, the structure is polymeric in the solid state. The solid adopts a layered structure but upon evaporation, the species becomes dimeric. In contrast VOCl<sub>3</sub> and VOBr<sub>3</sub> remain tetrahedral in all states, being volatile liquids at room temperature.
In organic synthesis, VOF<sub>3</sub> is used for the oxidative coupling of phenols, for example in the syntheses of vancomycin and its analogues. For these applications VOF<sub>3</sub> is typically dissolved in trifluoroacetic acid.
Vanadium(V) oxytrifluoride reacts with hexamethyldisiloxane to give vanadium dioxide fluoride: