In enzymology, an uronate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are D-galacturonate, NAD<sup>+</sup>, and H<sub>2</sub>O, whereas its 3 products are (the lactone of D-galactarate), NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is uronate:NAD<sup>+</sup> 1-oxidoreductase. Other names in common use include uronate: NAD-oxidoreductase, and uronic acid dehydrogenase.