Trans-resveratrol di-O-methyltransferase (, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase. This enzyme catalyses the following chemical reaction
2 S-adenosyl-L-methionine + trans-resveratrol 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
(1a) S-adenosyl-L-methionine + trans-resveratrol S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene S-adenosyl-L-homocysteine + pterostilbene
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
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