Thyromimetic drugs are synthetic agonists of the thyroid hormone receptor's isoforms TR ñ1, TRñ2, TRò1, or TRò2, mimicking some or all of the effects of endogenously produced thyroid hormones that regulate metabolism. Some thyromimetic drugs are selective for various of these receptors over others, enabling more targeted effects and reducing toxicity. Thyromimetics selective for TRòâÂÂincluding eprotirome, sobetirome, resmetirom, and the prodrug VK2809âÂÂhave been investigated for the treatment of non-alcoholic fatty liver disease, dyslipidemia, and other metabolic and neurodegenerative diseases.