L-threonine 3-dehydrogenase

In enzymology, L-threonine 3-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are L-threonine and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (S)-2-amino-3-ketobutyric acid, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-threonine:NAD⁺ oxidoreductase. Other names in common use include L-threonine dehydrogenase, threonine 3-dehydrogenase, and threonine dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

References