In organic chemistry, thienothiophene is any of several compounds consisting of two fused thiophene rings. They have the molecular formula C<sub>6</sub>H<sub>4</sub>S<sub>2</sub>. Three constitutional isomers have been synthesized: thieno[3,2-b]thiophene, thieno[2,3-b]thiophene, and thieno[3,4-b]thiophene. The other isomer features S(IV) and is less stable. Thieno[2,3-b]thiophene was the first member of the series to be isolated. It was obtained in very low yield upon heating citric acid, a source of a six-carbon linear chain, with P<sub>4</sub>S<sub>10</sub>. More efficient syntheses of this and the other two stable thienothiophenes involve cyclization reactions of substituted thiophenes.
Three thienothiophenes, being aromatic and bicyclic, are often compared to naphthalene. They are the topic of academic research. They have no commercial applications nor are they or their derivatives found naturally.