Tetrakis(trimethylsilyl)silane is the organosilicon compound with the formula (Me<sub>3</sub>Si)<sub>4</sub>Si (where Me = CH<sub>3</sub>). It is a colorless sublimable solid with a high melting point. The molecule has tetrahedral symmetry. The compound is notable as having silicon bonded to four other silicon atoms, like in elemental silicon.
The compound is prepared by the reaction of trimethylsilyl chloride, silicon tetrachloride, and lithium:
The compound is a precursor to tris(trimethylsilyl)silyl lithium by reaction with methyl lithium:
The organolithium compound (Me<sub>3</sub>Si)<sub>3</sub>SiLi is a versatile reagent, e.g. to tris(trimethylsilyl)silane ((Me<sub>3</sub>Si)<sub>3</sub>SiH).