Tetrahydrocortisol, or urocortisol, also known as 3ñ,11ò,17ñ,21-tetrahydroxy-5ò-pregnan-20-one, is a steroid and an inactive metabolite of cortisol.
Tetrahydrocortisol is a neurosteroid and has been found to act as a negative allosteric modulator of the GABA<sub>A</sub> receptor, similarly to pregnenolone sulfate.