TRNA (guanine<sup>6</sup>-N<sup>2</sup>)-methyltransferase (, methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine<sup>6</sup>-N<sup>2</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
The enzyme specifically methylates guanine<sup>6</sup> at N<sup>2</sup> in tRNA.