TRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase (, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase. This enzyme catalyses the following chemical reaction
tRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase from yeast does not catalyse the methylation from N<sup>2</sup>-methylguanine<sup>10</sup> to N<sup>2</sup>-dimethylguanine<sup>10</sup> in tRNA.