TRNA (guanine<sup>10</sup>-N<sup>2</sup>)-dimethyltransferase (, PAB1283, N(2),N(2)-dimethylguanosine tRNA methyltransferase, Trm-G10, PabTrm-G10, PabTrm-m2 2G10 enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine<sup>10</sup>-N<sup>2</sup>)-dimethyltransferase. This enzyme catalyses the following chemical reaction
2 S-adenosyl-L-methionine + guanine<sup>10</sup> in tRNA 2 S-adenosyl-L-homocysteine + N<sup>2</sup>-dimethylguanine<sup>10</sup> in tRNA (overall reaction)
(1a) S-adenosyl-L-methionine + guanine<sup>10</sup> in tRNA S-adenosyl-L-homocysteine + N<sup>2</sup>-methylguanine<sup>10</sup> in tRNA
(1b) S-adenosyl-L-methionine + N<sup>2</sup>-methylguanine<sup>10</sup> in tRNA S-adenosyl-L-homocysteine + N<sup>2</sup>-dimethylguanine<sup>10</sup> in tRNA
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