TRNASer (uridine<sup>44</sup>-2'-O)-methyltransferase (, TRM<sup>44</sup>) is an enzyme with systematic name S-adenosyl-L-methionine:tRNASer (uridine<sup>44</sup>-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
The 2'-O-methylation of uridine<sup>44</sup> contributes to stability of tRNASer(CGA).