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TRNA(His) guanylyltransferase

tRNA(His) guanylyltransferase (, histidine tRNA guanylyltransferase, Thg1p, Thg1) is an enzyme with systematic name p-tRNA(His):GTP guanylyltransferase (ATP-hydrolysing). This enzyme catalyses the following chemical reaction

p-tRNA(His) + ATP + GTP pppGp-tRNA(His) + AMP + diphosphate (overall reaction)
(1a) p-tRNA(His) + ATP App-tRNA(His) + diphosphate
(1b) App-tRNA(His) + GTP pppGp-tRNA(His) + AMP

The enzyme requires a divalent cation for activity.

Thg1 enzymes are the only nucleic acid polymerases known to be capable of catalyzing nucleotide addition in the 3′–5′ direction.

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