In enzymology, salutaridine reductase (NADPH) () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are salutaridine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. Its products are salutaridinol and oxidised NADPH<sup>+</sup>. This conversion is part of the morphinan alkaloid pathway in Papaver somniferum.
The enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is salutaridinol:NADP<sup>+</sup> 7-oxidoreductase.