Ribonucleotide reductase inhibitor

Ribonucleotide reductase inhibitors are a family of anti-cancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA).

Examples include:

• motexafin gadolinium.
• hydroxyurea
• fludarabine, cladribine, gemcitabine, tezacitabine, and triapine
• gallium maltolate, gallium nitrate
• Tezacitabine, Tezacitabine A chemotherapy candidate nucleotide analogue that failed in clinical trials due to on-target toxicity (febrile neutropenia).

See also

• Ribonucleotide reductase

References

External links

• Ribonucleotide reductase inhibitor entry in the public domain NCI Dictionary of Cancer Terms