23S rRNA (adenosine<sup>1067</sup>-2'-O)-methyltransferase (, 23S rRNA A1067 2'-methyltransferase, thiostrepton-resistance methylase, nosiheptide-resistance methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenosine<sup>1067</sup>-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction
The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus.