Quinbolone (, ), sold under the brand names Anabolicum and Anabolvis, is an androgen and anabolic steroid (AAS) which was previously marketed in Italy. It was developed by Parke-Davis as a viable orally administered AAS with little or no liver toxicity.
Most orally administered anabolic steroids function by having an alkylated 17ñ-carbon atom, which prevents first-pass metabolism by the liver. This approach however results in the AAS having hepatotoxicity. Quinbolone is not 17ñ-alkylated; instead it has increased oral bioavailability due to its cyclopentenyl ether group. After ingestion, the inactive quinbolone is transformed into boldenone.
Quinbolone itself has very few androgenic effects, and most of what it does have are a result of its conversion to boldenone and its metabolites. Because of high doses necessary for androgenic effects, cost and inconvenience meant that quinbolone never proved to be commercially successful, and its clinical applications were fulfilled by alternative, more effective, AAS. Its illicit usage in bodybuilding and athletics likewise proved limited, though drug tests are still used to detect its metabolites as it remains a banned substance for most competitive sports.
Quinbolone, via boldenone, can be transformed into estrogens, and hence may have some estrogenic activity.
Quinbolone, also known as ô<sup>1</sup>-testosterone 17ò-cyclopent-1-enyl enol ether or as androsta-1,4-dien-17ò-ol-3-one 17ò-(1-cyclopent-1-ene) enol ether, is a synthetic androstane steroid and a derivative of testosterone. It is the C17ò cyclopentyl enol ether of boldenone (ô<sup>1</sup>-testosterone). A related AAS is boldenone undecylenate (ô<sup>1</sup>-testosterone 17ò-undec-10-enoate).
Quinbolone can be prepared from testosterone. Dehydrogenation using DDQ forms boldenone. Reaction with 1,1-dimethoxycyclopentane followed by heating to eliminate methanol gives quinbolone.
Quinbolone was described as early as 1962. It was marketed in Italy by Parke-Davis.