The enzyme phosphopantothenoylcysteine decarboxylase () catalyzes the chemical reaction
This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .