Phospholipase B, also known as lysophospholipase, is an enzyme with a combination of both PLA<sub>1</sub> and PLA<sub>2</sub> activities; that is, it can cleave acyl chains from both the sn-1 and sn-2 positions of a phospholipid. In general, it acts on lysolecithin (which is formed by the action of PLA<sub>2</sub> on lecithin).