Phenylsilatrane is a convulsant chemical which has been used as a rodenticide. Phenylsilatrane and some of its analogs with 4-substituents of H, CH<sub>3</sub>, Cl, Br, and CSi(CH<sub>3</sub>)<sub>3</sub> are highly toxic to mice. They have been observed in the laboratory to inhibit the <sup>35</sup>S-tert-butylbicyclophosphorothionate (TBPS) binding site (GABA-gated chloride channel) of mouse brain membranes.