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Phenylglyoxylic acid

Phenylglyoxylic acid is the organic compound with the formula C<sub>6</sub>H<sub>5</sub>C(O)CO<sub>2</sub>H. The conjugate base, known as benzoylformate, is the substrate of benzoylformate decarboxylase, a thiamine diphosphate-dependent enzyme:

benzoylformate + H<sup>+</sup> benzaldehyde + CO<sub>2</sub>

It is a colourless solid with a melting point of 64–66&nbsp;°C and is moderately acidic (pK<sub>a</sub>&nbsp;=&nbsp;2.15).

Phenylglyoxylic acid can be synthesized by oxidation of mandelic acid with potassium permanganate. An alternative synthesis involves hydrolysis of benzoyl cyanide.

References