Peptidyl-glutamate 4-carboxylase (, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing). This enzyme catalyses the following chemical reaction
The enzyme can use various vitamin-K derivatives, including menaquinone.