Pendetide

Pendetide (GYK-DTPA) is a chelating agent. It consists of pentetic acid (DTPA) linked to the tripeptide glycine (G) – <small>L</small>-tyrosine (Y) – <small>L</small>-lysine (K).

Use

The following monoclonal antibodies are linked to pendetide to chelate a radionuclide, indium-111. The antibodies selectively bind to certain tumour cells, and the radioactivity is then used for imaging of the tumours.

• Indium (¹¹¹In) capromab pendetide (prostate cancer)
• Indium (¹¹¹In) satumomab pendetide (other cancer types)

References