Ofornine is a synthetic compound investigated primarily for its antihypertensive properties. It functions as a vasodilator and exhibits presynaptic adrenolytic activity, with evidence suggesting involvement of dopaminergic mechanisms in its pharmacological effects.
A number of structural analogs have been prepared with similar activity.
Ofornine contains a pyridine moiety, or more specifically a fampridine or anthranilamide (c.f. fenamate).
Synthesis: Patent:
Reaction between 4-chloropyridine [626-61-9] HCl: [7379-35-3] (1) and anthranilic acid [118-92-3] (2) gives 2-(4-pyridylamino)benzoic acid [34861-30-8] (3). Halogenation with thionyl chloride gave 2-(4-pyridinylamino)-benzoyl chloride [89989-83-3] (4). Amide formation with piperidine [110-89-4] (5) completed the synthesis of Ofornine (6).