Nicotianamine synthase () is an enzyme that catalyzes the chemical reaction
The enzyme converts three units of its substrate, S-adenosyl methionine, into nicotianamine and three units of 5â²-methylthioadenosine as a by-product.
This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-Lmethioni ne 3-amino-3-carboxypropyltransferase. Nicotianamine is a metal-chelating molecule ubiquitous in higher plants that assists in their uptake of metals from soil.