In enzymology, a myristoyl-CoA 11-(E) desaturase () is an enzyme that catalyzes the chemical reaction
The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H<sup>+</sup>, and O<sub>2</sub>, whereas its 4 products are (E)-11-tetradecenoyl-CoA, NAD<sup>+</sup>, NADP<sup>+</sup>, and H<sub>2</sub>O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating].