Mitochondrial pyruvate carrier

The mitochondrial pyruvate carriers are composed of:

• Mitochondrial pyruvate carrier 1
• Mitochondrial pyruvate carrier 2

The pyruvate carriers are involved in mitochondrial metabolism but it is possible to compensate for their loss of function. They have been studied for a role in cardiac stress adaption.

Inhibitors

MPC inhibitors include drugs like UK-5099 (JXL001), JXL069, and PP405.

References