Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid esterâÂÂspecifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ester of methylprednisolone. It acts as a prodrug of methylprednisolone. Methylprednisolone suleptanate was developed as an improved alternative to methylprednisolone acetate (Depo-Medrol) with greater water solubility for use by intravenous administration.