Methylecgonine, also known as ecgonine methyl ester is a prominent tropane alkaloid found in coca leaves. It is metabolite of cocaine, and may be used as a precursor for it. It also occurs as minor alkaloid in roots of many Datura species such as Datura stramonium and Datura innoxia.
Cocamine (a-Truxilline) aka isatropylcocaine [490-17-5] and isococamine (beta-Truxilline) [490-15-3] are alkaloids present in Erythroxylun truxillense Rusby. The Victorian era references disclosed in John Glasby's dictionary of alkaloids indicate the longevity of these compounds. Although these citations are outdated, a newer citation proposes different structures. These compounds are understood to be esters of truxillic acid and/or truxinic acid that are formed as a consequence of methylecgonine cinnamate photodimerizing. Cocamine was reported to be a heart poison in later work.
It is the last step before cocaine is biosynthesized in coca plants with the help of BAHD acyltransferase.
Animals study suggest that it has beneficial effect on cognition and protects against cocaine lethality. It showed inhibition of sodium channels only at very high dosages.