Malonyl-S-ACP decarboxylase (, malonyl-S-acyl-carrier protein decarboxylase, MdcD/MdcE, MdcD,E) is an enzyme with systematic name malonyl-(acyl-carrier-protein) carboxy-lyase. This enzyme catalyses the following chemical reaction
This enzyme comprises the beta and gamma subunits of the enzyme EC 4.1.1.88.