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Lovastatin nonaketide synthase

In enzymology, lovastatin nonaketide synthase () is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 8 malonyl-CoA + 11 NADPH + 10 H<sup>+</sup> + S-adenosyl-L-methionine dihydromonacolin L + 9 CoA + 8 CO<sub>2</sub> + 11 NADP<sup>+</sup> + S-adenosyl-L-homocysteine + 6 H<sub>2</sub>O

The 5 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, H<sup>+</sup>, and S-adenosyl-L-methionine, whereas its 6 products are dihydromonacolin L, CoA, CO<sub>2</sub>, NADP<sup>+</sup>, S-adenosyl-L-homocysteine, and H<sub>2</sub>O.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing).

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