In enzymology, an indoleacetaldoxime dehydratase () is an enzyme that catalyzes the chemical reaction
Hence, this enzyme has one substrate, (indol-3-yl)acetaldehyde oxime, and two products, (indol-3-yl)acetonitrile and H<sub>2</sub>O.
This enzyme belongs to the family of lyases, specifically the "catch-all" class of lyases that do not fit into any other sub-class. The systematic name of this enzyme class is (indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]. Other names in common use include indoleacetaldoxime hydro-lyase, 3-indoleacetaldoxime hydro-lyase, indole-3-acetaldoxime hydro-lyase, indole-3-acetaldehyde-oxime hydro-lyase, and (indol-3-yl)acetaldehyde-oxime hydro-lyase. This enzyme participates in cyanoamino acid metabolism.