Hematologic disease

Hematologic diseases are disorders which primarily affect the blood and blood-forming organs. Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease and complications from chemotherapy or transfusions.

Myeloid

• Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
• Sickle cell disease
• Thalassemia
• Methemoglobinemia
• Anemias (lack of red blood cells or hemoglobin)
• Iron-deficiency anemia
• Megaloblastic anemia
• Vitamin B₁₂ deficiency
• Pernicious anemia
• Folate deficiency
• Hemolytic anemias (destruction of red blood cells)
• Genetic disorders of RBC membrane
• Hereditary spherocytosis
• Hereditary elliptocytosis
• Congenital dyserythropoietic anemia
• Genetic disorders of RBC metabolism
• Glucose-6-phosphate dehydrogenase deficiency (G6PD)
• Pyruvate kinase deficiency
• Immune mediated hemolytic anemia (direct Coombs test is positive)
• Autoimmune hemolytic anemia
• Warm antibody autoimmune hemolytic anemia
• Idiopathic
• Systemic lupus erythematosus (SLE)
• Evans syndrome (antiplatelet antibodies and hemolytic antibodies)
• Cold autoimmune hemolytic anemia
• Cold agglutinin disease
• Paroxysmal cold hemoglobinuria (rare)
• Infectious mononucleosis
• Alloimmune hemolytic anemia
• Hemolytic disease of the newborn (HDN)
• Rh disease (Rh D)
• ABO hemolytic disease of the newborn
• Anti-Kell hemolytic disease of the newborn
• Rhesus c hemolytic disease of the newborn
• Rhesus E hemolytic disease of the newborn
• Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
• Drug induced immune mediated hemolytic anemia
• Penicillin (high dose)
• Methyldopa
• Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
• Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
• Direct physical damage to RBCs
• Microangiopathic hemolytic anemia
• Secondary to artificial heart valve(s)
• Aplastic anemia
• Fanconi anemia
• Diamond–Blackfan anemia (inherited pure red cell aplasia)
• Acquired pure red cell aplasia
• Decreased numbers of cells
• Myelodysplastic syndrome
• Myelofibrosis
• Neutropenia (decrease in the number of neutrophils)
• Agranulocytosis
• Glanzmann's thrombasthenia
• Thrombocytopenia (decrease in the number of platelets)
• Idiopathic thrombocytopenic purpura (ITP)
• Thrombotic thrombocytopenic purpura (TTP)
• Heparin-induced thrombocytopenia (HIT)
• Myeloproliferative disorders (Increased numbers of cells)
• Polycythemia vera (increase in the number of cells in general)
• Erythrocytosis (increase in the number of red blood cells)
• Leukocytosis (increase in the number of white blood cells)
• Thrombocytosis (increase in the number of platelets)
• Myeloproliferative disorder
• Transient myeloproliferative disease
• Coagulopathies (disorders of bleeding and coagulation)
• Thrombocytosis
• Recurrent thrombosis
• Disseminated intravascular coagulation
• Disorders of clotting proteins
• Hemophilia
• Hemophilia A
• Hemophilia B (also known as Christmas disease)
• Hemophilia C
• Von Willebrand disease
• Disseminated intravascular coagulation
• Protein S deficiency
• Antiphospholipid syndrome
• Disorders of platelets
• Thrombocytopenia
• Glanzmann's thrombasthenia
• Wiskott–Aldrich syndrome

Hematological malignancies

• Hematological malignancies
• Lymphomas
• Hodgkin's disease
• Non-Hodgkin's lymphoma {includes the next five entries}
• Burkitt's lymphoma
• Anaplastic large cell lymphoma
• Splenic marginal zone lymphoma
• Hepatosplenic T-cell lymphoma
• Angioimmunoblastic T-cell lymphoma (AILT)
• Myelomas
• Multiple myeloma
• Waldenström macroglobulinemia
• Plasmacytoma
• Leukemias increased WBC
• Acute lymphocytic leukemia (ALL)
• Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
• Acute myelogenous leukemia (AML)
• Acute megakaryoblastic leukemia (AMKL), a sub-type of acute myelogenous leukemia
• Chronic Idiopathic Myelofibrosis (MF)
• Chronic myelogenous leukemia (CML)
• T-cell prolymphocytic leukemia (T-PLL)
• B-cell prolymphocytic leukemia (B-PLL)
• Chronic neutrophilic leukemia (CNL)
• Hairy cell leukemia (HCL)
• T-cell large granular lymphocyte leukemia (T-LGL)
• Aggressive NK-cell leukemia

Miscellaneous

• Hemochromatosis
• Asplenia
• Hypersplenism
• Gaucher's disease
• Monoclonal gammopathy of undetermined significance
• Hemophagocytic lymphohistiocytosis
• Tempi syndrome

Hematological changes secondary to non-hematological disorders

• Anemia of chronic disease
• Infectious mononucleosis
• AIDS
• Malaria
• Leishmaniasis

References

External links

• https://web.archive.org/web/20100527085120/http://hematologic.niddk.nih.gov/info/index.htm