The enzyme glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) catalyzes the reaction
6-(ñ-<small>D</small>-glucosaminyl)-1-phosphatidyl-1<small>D</small>-myo-inositol = 6-(ñ-<small>D</small>-glucosaminyl)-1<small>D</small>-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 6-(ñ-<small>D</small>-glucosaminyl)-1-phosphatidyl-1<small>D</small>-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(ñ-<small>D</small>-glucosaminyl)-1<small>D</small>-myo-inositol 1,2-cyclic phosphate-forming].
Other names in common use include:
- GPI-PLC
- GPI-specific phospholipase C
- Glycosyl inositol phospholipid anchor-hydrolyzing enzyme
- Glycosylphosphatidylinositol-phospholipase C
- Glycosylphosphatidylinositol-specific phospholipase C or VSG-lipase
- Variant-surface-glycoprotein phospholipase C
- 6-(ñ-<small>D</small>-glucosaminyl)-1-phosphatidyl-1<small>D</small>-myo-inositol
- Diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
References