In enzymology, a glycoprotein O-fatty-acyltransferase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are palmitoyl-CoA and mucus glycoprotein, whereas its two products are CoA and O-palmitoylglycoprotein.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase. This enzyme is also called protein acyltransferase.