Glucose-1-phosphate thymidylyltransferase

In enzymology, a glucose-1-phosphate thymidylyltransferase () is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are dTTP and alpha-<small>D</small>-glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.

This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.

Nomenclature

The systematic name of this enzyme class is dTTP:alpha-<small>D</small>-glucose-1-phosphate thymidylyltransferase. Other names in common use include:

• glucose 1-phosphate thymidylyltransferase,
• dTDP-glucose synthase, dTDP-glucose pyrophosphorylase,
• thymidine diphosphoglucose pyrophosphorylase,
• thymidine diphosphate glucose pyrophosphorylase, and
• TDP-glucose pyrophosphorylase.

Structural studies

As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , and .

References