In enzymology, a gluconate 2-dehydrogenase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are D-gluconate and NADP<sup>+</sup>, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-gluconate:NADP<sup>+</sup> oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.