The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:
- Plasma free fraction, previously referred to as ÃÂ<sub>1</sub>, is now referred to as ÃÂ<sub>P</sub> according to consensus nomenclature.
- Tissue free fraction (ÃÂ<sub>ND</sub>), previously referred to as ÃÂ<sub>2</sub>
The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.
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