Flavonoid 3′-monooxygenase

Flavonoid 3′-monooxygenase (, originally classified as ) is an enzyme that catalyzes the chemical reaction

For example, naringenin is converted to eriodictyol:

The enzyme uses molecular oxygen and reduced nicotinamide adenine dinucleotide phosphate (NADPH) to insert a hydroxy group into a specific position in one of the benzene rings of the starting material.

It is a cytochrome P450 protein containing heme which acts as an oxidoreductase. The systematic name of this enzyme class is flavonoid,NADPH:oxygen oxidoreductase (3′-hydroxylating). Other names in common use include flavonoid 3′-hydroxylase, flavonoid 3-hydroxylase (erroneous), NADPH:flavonoid-3′-hydroxylase, and flavonoid 3-monooxygenase (erroneous). In palnts including Matthiola incana from which it was first characterised, it is part of the pathway to anthocyanins.

References