Fatty acid oxidation inhibitors

Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.

Drugs

• CPT-I inhibitors: etomoxir, oxfenicine, perhexiline <br/> CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine.
• Carnitine biosynthesis inhibitor: mildronate
• 3-KAT inhibitors: trimetazidine <br/> 3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation.
• pFOX directly inhibits fatty acid beta-oxidation.

References