ent-Pimara-9(11),15-diene synthase (EC 4.2.3.31, PMD synthase) is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase (ent-pimara-9(11),15-diene-forming). This enzyme catalyses the following chemical reaction
This enzyme is involved in the biosynthesis of the diterpenoid viguiepinol and requires Mg<sup>2+</sup>, Co<sup>2+</sup>, Zn<sup>2+</sup> or Ni<sup>2+</sup> for activity.