Ent-kaurene oxidase (, Formerly ) is an enzyme with systematic name ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating). This enzyme catalyses the following chemical reaction
ent-kaur-16-ene + 3 NADPH + 3 H<sup>+</sup> + 3 O<sub>2</sub> ent-kaur-16-en-19-oate + 3 NADP<sup>+</sup> + 4 H<sub>2</sub>O (overall reaction)
(1a) ent-kaur-16-ene + NADPH + H<sup>+</sup> + O<sub>2</sub> ent-kaur-16-en-19-ol + NADP<sup>+</sup> + H<sub>2</sub>O
(1b) ent-kaur-16-en-19-ol + NADPH + H<sup>+</sup> + O<sub>2</sub> ent-kaur-16-en-19-al + NADP<sup>+</sup> + 2 H<sub>2</sub>O
(1c) ent-kaur-16-en-19-al + NADPH + O<sub>2</sub> ent-kaur-16-en-19-oate + NADP<sup>+</sup> + H<sub>2</sub>O
Ent-kaurene oxidase requires cytochrome P450 and is inhibited by paclobutrazol.
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